I would pick between the 16F large or the IQ Hardwire PowerG. The small enclosure would not allow for a clean install.
The IQ Hardwire PowerG does have a few more features like the 4 on board PGM’s, it can handle both 2 wire and 4 wire smokes, and is expandable up to 40 zones with IQ Hardwired Expansion Card but only 2 expansion cards fit in the enclosure. While it can be expanded to more zones, it starts with 8 zones. The Hardwire PowerG runs on PowerG communication. More information on PowerG below
The 16F cannot be expanded and would require a second 16F if you need more than 16 zones and can handle 2-wire smoke detectors. The 16F runs on 319.5Mhz.